Instruction For Submission

Because of page limitations, the Editors require that manuscripts not exceed 4,500 words (including references and figure legends). Illustrations and tables should be limited to those necessary to highlight key data. The manuscript should be arranged as follows: 1) title page; 2) structured abstract and key words; 3) abbreviations list; 4) text; 5) acknowledgments (if applicable); 6) references; 7) figure titles and legends; and 8) tables. Page numbering should begin with the title page.

Paper Categories

The following information should be noted for these paper types:

Original Research

  • Original Articles are scientific reports of the results of original clinical research. The text is limited to 3000 words, with an abstract, a maximum of 5 tables and figures (total), and up to 40 references.
  • Special Articles are scientific reports of original research in such areas as economic policy, ethics, law, and health care delivery. The text is limited to 3000 words, with an abstract, a maximum of 5 tables and figures (total), and up to 40 references.

Clinical Cases

  • Brief Reports usually describe one to three patients or a single family. The text is limited to 2000 words, a maximum of 3 tables and figures (total), and up to 25 references.

Review Articles

Review articles are usually solicited by the editors, but we will consider unsolicited material. Please contact the editorial office before writing a review article for the Journal. All review articles undergo the same peer-review and editorial process as original research reports.

  • Clinical Practice articles are evidence-based reviews of topics relevant to practicing physicians, both primary care providers and specialists. Articles in this series should include the following sections: the clinical problem, strategies and evidence, areas of uncertainty, guidelines from professional societies, and the authors' conclusions and recommendations. The text is limited to 2500 words and a small number of figures and tables.
  • Current Concepts articles focus on clinical topics, including those in specialty areas but of wide interest. The text is limited to 2400 words, with a maximum of 4 figures and tables (total), and up to 50 references.
  • Drug Therapy articles detail the pharmacology and use of specific drugs or classes of drugs, or the various drugs used to treat particular diseases. The text is limited to 4000 words, with a maximum of 6 figures and tables (total), and up to 60 references.

Other Submissions

  • Perspective articles cover a wide variety of topics of current interest in health care, medicine, and the intersection between medicine and society. We welcome submissions and proposals. Perspective articles are limited to 2000 words and can include up to 3 figures.
  • Clinical Implications of Basic Research articles discuss single papers from preclinical journals. The purpose is to explain the findings and comment on their possible clinical applications in fewer than 750 words. There may be 1 figure and up to 4 references. We do not consider unsolicited manuscripts in this category.
  • Special Reports are miscellaneous articles of special interest to the medical community. They are limited to 2700 words.

Manuscript Content

Title Page
Include the title, authors’ names (including full first name and middle initial, degrees and a brief title of no more than 45 characters. List the departments and institutions with which the authors are affiliated, and indicate the specific affiliations if the work is generated from more than one institution. Also provide information on grants, contracts, and other forms of financial support.  Include any relationship with industry (see “Relationship with Industry Policy”). Under the heading, “Address for correspondence,” give the full name and complete postal address of the author to whom communications should be sent. Also provide telephone numbers and an e-mail address.

Structured Abstract
Provide a structured abstract of no more than 250 words, presenting essential data in 5 paragraphs introduced by separate headings in the following order: Objectives, Background, Methods, Results, and Conclusions. Use complete sentences. All data in the abstract must also appear in the manuscript text or tables. A nonstructured abstract is appropriate for review articles.

Text
The text should be structured as Introduction, Methods, Results, and Discussion. Use headings and subheadings in the Methods, Results, and, particularly, Discussion sections. Every reference, figure and table should be cited in the text in numerical order according to order of mention.
To save space abbreviations of common terms or acronyms may be used throughout the manuscript. On a separate page following the structured abstract, list the selected abbreviations and their definitions.

Acknowledgments
Acknowledgments or appendices must contain 100 words or less. Anything exceeding this limit will appear in the online version only.

References
Identify references in the text by Arabic numerals in parentheses on the line. The reference list should be typed double-spaced on pages separate from the text; references must be numbered consecutively in the order in which they are mentioned in the text. Do not cite personal communications, manuscripts in preparation or other unpublished data in the references; these may be cited in the text in parentheses. Use Index Medicus (National Library of Medicine) abbreviations for journal titles.

Use the following style and punctuation for references:

Periodical - List all authors if six or fewer, otherwise list the first three and add the et al.;  Please provide inclusive page numbers as in example below.

5. Glantz SA. It is all in the numbers. J Am Coll Cardiol 1993;21:835–7.

Chapter in book - Provide inclusive page numbers, authors, chapter titles, book title, editor, publisher and year.

27. Meidell RS, Gerard RD, Sambrook JF. Molecular biology of thrombolytic agents. In: Roberts R, editor. Molecular Basis of Cardiology. Cambridge, MA: Blackwell Scientific Publications, 1993:295–324.
Book (personal author or authors) - Provide a specific (not inclusive) page number.

23. Cohn PF. Silent Myocardial Ischemia and Infarction. 3rd ed. New York, NY: Marcel Dekker, 1993:33.
Online Media - Provide specific URL address and date information was accessed.
10. Henkel J. Testicular Cancer: Survival High With Early Treatment. FDA Consumer magazine [serial online]. January–February 1996. Available at: www.fda.gov/fdac/features/196_test.html. Accessed August 31, 1998.
Material presented at a meeting but not published  - Provide authors, presentation title, full meeting title, meeting dates, and meeting location.

20. Eisenberg J. Market forces and physician workforce reform: why they may not work. Paper presented at: Annual Meeting of the Association of Medical Colleges; October 28, 1995; Washington, DC.

Figure Legends
Figure legends should be typed double-spaced on pages separate from the text; figure numbers must correspond with the order in which they are mentioned in the text. All figures must have a title as well as a caption. For example, Figure 1: Title - Caption, etc. All abbreviations used in the figure should be identified either after their first mention in the legend or in alphabetical order at the end of each legend. All symbols used (arrows, circles, etc.) must be explained. If previously published figures are used, written permission from the original publisher is required. Cite the source of the figure in the legend.

Figures
Figures and graphs submitted in electronic format should be provided in EPS or TIF format. Colour images must be at least 300 DPI. Gray scale images should be at least 300 DPI. Line art (black and white or colour) should be at least 1200 DPI and combinations of gray scale images and line art should be at least 1200 DPI. Lettering should be of sufficient size to be legible after reduction for publication. The optimal size is 12 points. Symbols should be of a similar size. Figures should be no smaller than 13 cm × 18 cm (5"×7"). Please do not reduce figures to fit publication layout. If the manuscript is accepted for publication, the publisher will re-size the figures accordingly. ALL FIGURES MUST HAVE A TITLE AND CAPTION.

Tables
Tables should be typed double-spaced on separate sheets, with the table number and title centred above the table and explanatory notes below the table. Use Arabic numbers. Table numbers must correspond with the order cited in the text. ALL TABLES MUST HAVE A TITLE.

Abbreviations should be listed in a footnote under the table in alphabetical order. Tables should be self-explanatory, and the data presented in them should not be duplicated in the text or figures. If previously published tables are used, written permission from the original publisher and author is required. Cite the source of the table in the footnote.