A Review of Risk Factors and Cardiovascular Disease in Diabetes Care - 2011

REVIEW, July 2011, VOL I ISSUE III, ISSN 2042-4884
10.5083/ejcm.20424884.43 , Cite or Link Using DOI
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Jan Cederholm, Peter M Nilsson

This review presents results from recent trials and observational studies on risk factors and cardiovascular disease. Treatment goals are provided that should be preferable for most patients in diabetes care, even if these recommendations should be combined with clinical judgement and individual preferences.

HbA1c as risk factor for cardiovascular disease

Evidence exists today from observational studies that hyperglycemia is an important risk factor for cardiovascular diseases, with a risk increase per 1 %-unit increase in HbA1c of 27% in type 1 diabetes (1) and 11-16% in type 2 diabetes (2, 3), independently of clinical characteristics and other traditional risk factors. A risk reduction by glucose-lowering has most obviously been demonstrated in patients with type 1 diabetes, often younger or middle-aged with less traditional risk factors than patients with type 2 diabetes.