ACE I/D and ADD1 Polymorphisms in Individuals with Cardiovascular Diseases: Prospects on Risk Assessment and Pharmacogenetics

ORIGINAL RESEARCH, December2013, VOL II ISSUE IV, ISSN 2042-4884
10.5083/ejcm.20424884.106 , Cite or Link Using DOI
Creating a Digital Object Identifier Link

A digital object identifier (DOI) can be used to cite and link to electronic documents. A DOI is guaranteed never to change, so you can use it to link permanently to electronic documents.

To find a document using a DOI

  1. Copy the DOI of the document you want to open.
    The correct format for citing a DOI is as follows: doi:10.1016/S0140-6736(08)61345-8
  2. Open the following DOI site in your browser:
    dx.doi.org
  3. Enter the entire DOI citation in the text box provided, and then click Go.
    The document that matches the DOI citation will display in your browser window.

The DOI scheme is administered by the International DOI Foundation. Many of the world's leading publishers have come together to build a DOI-based document linking scheme known as CrossRef.

Roldan M. de Guia, Francesca Paola D.G. Aguirre, Angeli Kaye M. Calderon, Harold Ian Y. Gamboa, Laine Valerie C. Kongsun Ching, Bernadette Meifel Joyce D. Madamba, Lorenz Jacob C. Mangahas, Ma. Victoria P. Policina, Rachel R. Santos, et al

ABSTRACT

Objective:
To assess the frequency of ACEI/D and ADD1 polymorphism in recruited Filipino populations, identify risk factors, and most popular mode of medications.

Methods and Results: Case-series and case-control samplings were done. Hypertension proved to be the most common case in the population. Other important risk factors identified are age, body mass index, physical activity, and family history. ACE I/D and ADD1 G460W polymorphisms were genotype using PCR-based methods. It was identified from the screenings that the ACE deletion and ADD1 W460 alleles are prevalent in cases of CVDs although hypertension in the population is not associated with the ACE I/D polymorphism (χ2=0.09, p=0.956). On the contrary, comorbidity of diabetes and CVDs is associated with ACE I/D polymorphism with II genotyped conferring the risk (OR=5.4375, 95% CI: 2.2275-13.2735, p=0.0002). Majority of CVD cases in the study were using
beta-blockers, ACE inhibitors, calcium channel blockers, and statins.

Conclusion: With these preliminary data at hand, future studies are geared toward bigger population-based screening for risk assessment and selection of genes that could possibly affect metabolism and efficacy of drugs that are commonly used by Filipinos.