Comparative Effects of Injectable and Oral Hormonal Contraceptives on Lipid Profile

10.5083/ejcm.20424884.64 , Cite or Link Using DOI
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Chukwubike U.Okeke, Solomon A. Braide, Benjamin N. Okolonkwo, Roseanne Okafor, Pascal C. Eneh, Adebayor Adegoke, Holy Brown, Ngozika B. Okwandu


Background  and Aims

The continual use of hormonal contraceptives among women within reproductive age has been on the increase. The effects of these contraceptives on lipid metabolism vary depending on the type of hormonal contraceptive. This study was carried out among Nigerian women, to compare the effects of injectable hormonal contraceptives to that of combined oral contraceptives on lipid profile (triglyceride, total cholesterol, high density lipoprotein-cholesterol and low density lipoprotein-cholesterol).


The lipid profile of a total of 83 women (50 of whom were non-users of  contraceptives while the remaining 33 used different hormonal contraceptives; 26 of them used the injectable hormonal contraceptives while 7 used oral contraceptives) were estimated using enzymatic methods except low density lipoprotein- cholesterol (LDL-C) which was by calculation.


There was a significant change (p < 0.05) in triglyceride (TG) and LDL-C levels, and no significant change (p > 0.05) in total cholesterol (TC) and high density lipoprotein- cholesterol (HDL-C) levels in women on oral contraceptives, while in injectable hormonal contraceptive users, there was significant change (p < 0.05) in HDL-C and LDL-C, and no significant change in TG and TC levels. The Castelli risk index I and II (TC/HDL-C and LDL-C/HDL-C) were more reduced in women using injectable contraceptives (1.65 and 0.45,  respectively) than in oral contraceptive users (1.80 and 0.56,


The result indicated that the use of injectable hormonal contraceptives is more beneficial than combined oral contraceptives among these women.