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Echocardiographic assessment of adult Nigerian sickle cell patients with pulmonary hypertension.

ORIGINAL RESEARCH, January 2015, VOL III ISSUE I, ISSN 2042-4884
10.5083/ejcm.20424884.132 , Cite or Link Using DOI
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N.I. Oguanobi, E.C. Ejim, B.C. Anisiuba, B.J.C. Onwubere, S.O. Ike, O.G. Ibegbulam

ABSTRACT

Background:
Descriptive data on relationship of pulmonary hypertension and echocardiographic indices of cardiac function in sickle cell anaemia is scant.

Objective: This study was carried out to assess the relationship of elevated pulmonary artery pressure and echocardiographic measures of cardiac dimensions and function in adult Nigerians with sickle cell anaemia.

Methods: Sixty two sickle cell anaemia patients and sixty two age and sex matched normal controls were studied. All the subjects had clinical evaluation, and echocardiographic examinations.

Results: Pulmonary hypertension was associated with increased left ventricular dimension (left ventricular end systolic dimension, left ventricular mass, and left ventricular mass index). Significant correlation was found between pulmonary artery pressure and (1) left ventricular end systolic dimension {r= 0.285; p =0.025}, (2) left ventricular end diastolic dimension {r = 0.303; p = 0.017}, (3) left ventricular mass {r = 0.252; p = 0.048}. Transmitral E/A ratio showed a negative correlation with pulmonary artery pressure {r = 0.269; p = 0.034}.

Conclusion: Increased pulmonary artery pressure exerts negative impact on left ventricular diastolic and systolic function in sickle cell anaemia.