Hearing Loss Due to Familial Hypercholesterolemia and Statin Treatment

ORIGINAL RESEARCH, October 2013, VOL II ISSUE IV, ISSN 2042-4884
10.5083/ejcm.20424884.104 , Cite or Link Using DOI
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Muhammed Oylumlu, Faris Mahmode Lolan MD, Suleyman Ercan MD, Gokhan Altunbas MD, Zeynel Karatas MD, Vedat Davutoglu MD

ABSTRACT
It has been suggested that high cholesterol levels might have adverse effects on hearing and interestingly statins may have beneficial effects on hearing loss. Herein, we share a dramatic improvement in acute hearing loss by statin administration in a young patient with familial hypercholesterolemia. To our knowledge this is the first report indicating the possible role of statins in patients suffering from sudden hearing loss in the context of familial hypercholesterolemia. Although the statin administration as a therapeutic option for sudden hearing loss needs to be clarified in prospective studies, this case report might shed more light for possible association of dyslipidemia and hearing loss and role of statins in such cases.

INTRODUCTION

Familial Hypercholesterolemia (FH) is a common autosomal dominant disorder of lipoprotein metabolism with a prevalence of 1 in 500 for the heterozygous form and one in a million for the homozygous form. FH is characterized by elevated LDL cholesterol levels, tendon xanthomatas, arcus cornea and increased risk of coronary heart disease. The homozygous form of FH has a gloomier prognosis and depending on the type of the mutation may cause death in the early decades of life. Several different factors may affect the manifestations of FH such as age, gender, diet, type of LDL receptor mutations and other gene mutations.