High Sensitivity Troponin T as a Marker of Silent Myocardial Injury in Diabetics

ORIGINAL RESEARCH, May 2014, VOL III ISSUE I, ISSN 2042-4884
10.5083/ejcm.20424884.115 , Cite or Link Using DOI
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Priyanka Datta, Pragna Rao.

Introduction: The new high sensitivity (hs) troponin T is specific biomarkers of myocardial necrosis. It has significant benefits for early recognition of acute myocardial infarction. CK-MB in serum is an important marker in diagnosis of myocardial ischemia.

Aim and objective: We aimed to analyse and compare the relationship between glycated haemoglobin levels and hs troponin T, CK-MB in chronic hyperglycaemic patients as a marker of silent micro infarcts.

Method and materials: hs Troponin T and CK-MB levels were measured using ECLIA and glycated haemoglobin by using HPLC method by variant turbo II.
We grouped 119 chronic diabetic aged 30 - 70yrs in three categories according to HbA1c level Group A <6.5%, group B 6.5 – 8% and group C>8 %. Diabetic patients with cardiovascular disorder, renal failure, sepsis, skeletal muscle disorder and acute cholecystitis were excluded.

Results: There was a 4 fold increase in values of hsTrop T in group II while 9.4 fold for group III in comparison to group I. CK-MB was elevated by 2.7 fold in group II and 3.11 in group III in comparison to group I.

Conclusion: The prevalence of detectable hs-cTnT was increased in diabetic population and found specific than CK-MB to diagnose minimal myocardial cell injury. Troponin T levels can be used to detect early and minimal myocardial cell injury even in the presence of normal CK-MB. These data raise the possibility that hs Troponin T can be used as a predictor of minimal cardiac injury and micro infract in diabetic patients before symptoms manifest.