Hyperkalemia in Cardiovascular Patients and Emerging Therapies

REVIEW, September 2015, VOL IV ISSUE I, ISSN 2042-4884
10.5083/ejcm.20424884.141 , Cite or Link Using DOI
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Insara Jaffer Sathick MBBS MRCP, Kianoush B Kashani MD

ABSTRACT

Hyperkalemia is a commonly encountered electrolyte disorder in clinical practice. Severe hyperkalemia can lead to life-threatening cardiac arrhythmias and death. In patients with cardiovascular and chronic kidney disease, it is a major limiting factor for the use of medications that work by blocking the renin angiotensin aldosterone system. Recently, three randomised-controlled trials have been published on novel medications that may be of benefit in patients who are considered high risk for hyperkalemia. In the future, the use of these novel agents may potentially
allow safer renin angiotensin aldosterone system blockade. In this review, we discuss these emerging therapies, as well as a pragmatic approach to the management of hyperkalemia in the cardiovascular disease patient.