Optimal Antihypertensive Combination Treatments

REVIEW, March 2012, VOL II ISSUE I, ISSN 2042-4884
10.5083/ejcm.20424884.76 , Cite or Link Using DOI
Creating a Digital Object Identifier Link

A digital object identifier (DOI) can be used to cite and link to electronic documents. A DOI is guaranteed never to change, so you can use it to link permanently to electronic documents.

To find a document using a DOI

  1. Copy the DOI of the document you want to open.
    The correct format for citing a DOI is as follows: doi:10.1016/S0140-6736(08)61345-8
  2. Open the following DOI site in your browser:
    dx.doi.org
  3. Enter the entire DOI citation in the text box provided, and then click Go.
    The document that matches the DOI citation will display in your browser window.

The DOI scheme is administered by the International DOI Foundation. Many of the world's leading publishers have come together to build a DOI-based document linking scheme known as CrossRef.

Massimo Volpe, Giuliano Tocci, Sami A. Omar

Over the past three decades it has been consistently shown that optimal blood pressure (BP) control significantly reduced cardiovascular (CV) morbidity and mortality. Despite solid evidence in favour of benefits derived from BP reductions, however, hypertension control in treated hypertensive patients remains suboptimal worldwide. In addition, proportions of diagnosed and treated hypertensive patients remain largely unchanged over the last two decades. Multiplefactors may be advocated to explain this observation, including variation in healthcare access and availability, attitudes amongst clinicians towards hypertension, inaccuracy in BP measurements and underuse or under dosage of  antihypertensive drugs in both monotherapy and in combination therapy.

On the basis of these considerations, it is beyond the aim of this article to discuss the socioeconomic impact on healthcare and BP measurement techniques. Instead it will seek to explain the importance of attaining early optimal BP control and the use of combination therapy as a new paradigm for the modern clinical management of hypertension.