Adverse Effects of Short-term Exposure to PM2.5 on the Onset of Acute Myocardial Infarction

10.5083/ejcm.20424884.131 , Cite or Link Using DOI
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Tsuyoshi Honda, MD, Kazuteru Fujimoto MD, Yuji Miyao MD

Background: The adverse effects of exposure to particulate matter ≤2.5 μm in diameter (PM2.5) on the onset and outcomes of acute myocardial infarction (AMI) were controversial. This study was conducted to clarify the association between exposure to PM2.5 and AMI.

Methods:  We studied 478 consecutive patients admitted with AMI. O-days were defined as days with ≥1 patient/day admitted for AMI, and NO-days were defined as days with <1 patient/day. F-days were defined as days with ≥2 patients/day admitted for AMI, and NF-days were defined as days with <2 patients/day. L-days were defined as days with ≥1 patient/day admitted for AMI who died during hospitalisation, and NL-days defined as days with <1 patient/day admitted for AMI who died during hospitalisation. Mean and maximum levels for PM2.5 at onset and 1, 2, 3, 4 and 5 days before onset were available from the Kumamoto prefecture office.

Results: There were no significant differences in mean PM2.5 levels between O- and NO-days or F-and NF-days. In contrast, maximum PM2.5 levels on O-days were significantly higher than those on NO-days 3 days before onset. There was a tendency for maximum PM2.5 levels on F-days to be increased compared to those on NF-days 3 days before onset. However, no significant difference in PM2.5 levels was found between L- and NL-days. Multiple logistic regression analysis showed that the onset of AMI was associated with maximum PM2.5 levels 3 days prior (odds ratio, 1.01; p<0.05).

Conclusions: Short-term PM2.5 exposure may be associated with the onset of AMI.