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Atherosclerosis In The Person With Diabetes

PERSPECTIVE, 14 October 2009, VOL I ISSUE I, ISSN 1756-0993
doi: 10.5083/ejcm.20424884.06 , Cite or Link Using DOI
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Sudha Karnwal MBBS, Yasmin Hamirani MD, Irfan Zeb MD, Matthew J. Budoff, MD, FACC, FAHA

Persons with diabetes, whether symptomatic or asymptomatic, are predisposed to developing atherosclerosis. Atherosclerosis occurs earlier and progresses more rapidly in diabetics than in non-diabetic people. Those at high risk for future myocardial infarction and coronary artery disease can be identified by the determination of coronary artery calcium (CAC) independent of accompanying cardiovascular risk factors. Available studies demonstrate that CAC predicts CV events better than either Intima - Media Thickness or C reactive protein. In the presence of calcification, aggressive medical therapy should be given and potentially intensified depending on the degree of calcification. Diabetics with a CAC 0 are at a very low risk of developing cardiovascular events (0% in most studies to date) but long term data and prospective evaluation is lacking.

Matthew Budoff, MD, Los Angeles Biomedical, Research Center, 1124 West Carson Street, Torrance, CA 90502


diabetes mellitus, cardiovascular risk, atherosclerotic plaque burden, coronary artery disease, atherosclerosis