Clinical Features and Main Determinants of Coronary Slow Flow Phenomenon in Iranian Patients

ORIGINAL RESEARCH, Summer 2010, VOL I ISSUE II, ISSN 2042-4884
10.5083/ejcm.20424884.15 , Cite or Link Using DOI
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Mansour Moazenzadeh, Behzad Sarvar Azimzadeh, Jahangir Zare, Mohammad Shokouhi & Mehrdad Sheikhvatan

ABSTRACT


Objectives: The present study addresess the associated clinical profile and main clinical determinants of coronary slow flow phenomenon (CSFP) among Iranians.

Background: CSFP may have a high incidence of clinical risk profiles as well as metabolic syndrome which leads to development of coronary microvascular dysfunction.

Methods: Our study population consisted of 46 patients with normal coronary arteries but documented CSFP on coronary arteriography and 92 control group patients with normal coronary arteries and normal coronary flow matched for age and gender. Coronary blood flow was measured quantitatively using the Thrombolysis in Myocardial Infarction (TIMI) frame count and slow flow was defined as TIMI grade 2 standard deviations (SD) from normal published range.

Results: Overall incidence of systolic hypertension and diabetes mellitus were significantly higher in the CSFP group. Opium addiction was also more frequent in those with CSFP. There were however no significant differences in age distribution, current smoking and hyperlipiemia between the two groups.
Multivariable logistic analysis showed that the two factors of opium addiction (OR = 3.807, p = 0.006) and diabetes mellitus (OR = 7.067, p = 0.020) were main independent predictors of CSFP with the presence of demographic variables as cofounders.

Conclusion: The presence of CSFP may be dependant on vascular dysfunction relate to impaired glucose tolerance and regular opium use.