Dynamic Changes of Cardiac Biomarkers in Non-ST-elevation Myocardial Infarction

10.5083/ejcm.20424884.157 , Cite or Link Using DOI
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Maryam Nabati, Bahareh Golestani, Jamshid Yazdani, Mozhdeh Dabirian, Homa Parsaee


Objective: Creatine kinase-myocardial band (CK-MB) and troponin-I are the most specific and ac- curate indicators of myocardial infarction among different cardiac biomarkers. However, few studies have examined the correlation between dynamic changes of these biomarkers and high risk echo- cardiographic and angiographic variables. The aim of our study was to assess the relationship be- tween these variables.

Methods: Our study was a prospective study of 113 patients with a diagnosis of non-ST-elevation myocardial infarction (NSTEMI) who were admitted within 24 hours of the onset of symptoms. Tro- ponin-I and CK-MB were measured serially at the time of hospital admission, at 6-9 hours and again at 12-24 hours. All patients underwent transthoracic echocardiography and coronary angiography and left ventricular ejection fraction (LVEF), mitral regurgitation and severity of coronary artery disease were determined. Patients were followed for 3 months to assess the need for coronary re- vascularization.

Results: There was significant correlation between troponin-I levels within 6-9 hours after admis- sion and the need for revascularization (P Value 0.036). Also, patients younger than 65 years of age had higher levels of troponin-I in both at the time of admission and within 6-9 hours after admis- sion (P Value 0.010 and 0.005, respectively). On the other hand, both patients with LVEF<45% and hypertensive patients had higher levels of CK-MB within 6-9 hours and 12-24 hours (P Value 0.043 and 0.039 for LVEF and 0.021 and 0.003 for hypertension, respectively).

Conclusion: Dynamic changes of troponin-I and CK-MB after NSTEMI can be an important indicator for risk stratifying of these patients.