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Eprosartan and Cognitive Function

SHORT REPORT, 10 November 2009, VOL I ISSUE I, ISSN 1756-0993
doi: 10.5083/ejcm.20424884.07 , Cite or Link Using DOI
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Atul Pathak

Due to its high frequency and associated health risks, hypertension has become an important world¬wide health challenge. Midlife hypertension is one of the principal risk factors for cerebrovascular diseases; recent studies have indicated a relationship between hypertension and cognitive function.

There is an active brain renin–angiotensin system (RAS) and angiotensin -converting enzyme (ACE) circulating angiotensin 2 and receptors AT1-AT4 that have all been found in the brain. Increased activity of the RAS and increased levels of ACE have also been associated with cognitive impairment. Animal and experimental data have shown that increases in RAS activity have an effect on the acetylcholine pathway, explaining why patients with activated RASs are at higher risk of developing cognitive impairment.

The link between antihypertensive treatment and improvement in cognitive function has yet to be conclusively proved, and there is a still a growing consensus that possible effects of antihypertensive treatment on cognitive function should be an area of continuing scrutiny but it is important for cardiologists treating individuals with hypertension to be aware that they should consider the mind as well as the heart when deciding on a suitable antihypertensive therapy for their patients.

Atul PATHAK MD, PhD Professor of Clinical Pharmacology, University Hospital, Toulouse, Servicede Pharmacologie Clinique Unité INSERM U 858Faculté de Médecine37 Allées Jules Guesde31000 Toulouse-


antihypertensive therapy, eprosartan, cognitive function