Frequency of Clopidogrel Resistance in Patients of Ischemic Heart Disease

ORIGINAL RESEARCH, May 2013, VOL II ISSUE III, ISSN 2042-4884
10.5083/ejcm.20424884.93 , Cite or Link Using DOI
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Syed Khizar Abbas Rizvi, Shahida Mohsin, Tahir Saeed, Saeed Ahmad, Shabbir Hussain, Muhammad Ikram Ullah

ABSTRACT:

Clopidogrel and Aspirin are widely used antiplatelet agents in the prevention and treatment of ischemic heart disease (IHD). Many patients have been noticed with recurrence of major ischemic events, due to resistance of these drugs. Different platelet function tests can be used to evaluate the degree of achieved platelet inhibition in patients treated with clopidogrel. The objective of this study was to determine frequency of clopidogrel resistance in patients of ischemic heart disease. Seventy one patients of IHD were selected from out-patient department of Punjab Institute of Cardiology Lahore. Platelet aggregation studies were performed on Diamed Impact R. Clopidogrel response assay was performed with DiaAdin(ADP 110μmol/L). Chi-square test was applied to measure statistical significance. Resistance to Clopidogrel was observed in 17% (12 out of 71).

Clopidogrel resistance was significantly associated with female gender (p=0.046). In our study no statistically significant association was observed between clopidogrel resistance and risk factors like diabetes mellitus, family history ischemic heart disease, hypertension and smoking. We concluded that resistance to Clopidogrel therapy is seen in significant number of patients and female patients are at high risk of developing the resistance to clopidogrel therapy. These patients can be identified by performing platelet aggregation studies on Impact R.