Insight Into the Molecular and Genetic Changes in Heart Failure

REVIEW, Summer 2010, VOL I ISSUE II, ISSN 2042-4884
10.5083/ejcm.20424884.13 , Cite or Link Using DOI
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Sergio Dalla–Volta, MD, PhD, Distinguished Professor of Cardiology, Department of Cardiovascular and Thoracic Sciences, University of Padova, Medical School

In the last fifteen years much progress has been made on the knowledge of the mechanisms controlling the genetic and molecular activities of the mammalian (with special emphasis on the human) heart in chronic cardiac insufficiency.

This increased knowledge has greatly influenced the understanding and treatment of heart failure, helping to prolong duration of life; even if clear evidence of a long lasting improvement of the syndrome is lacking.

The causes of heart failure are numerous and different, but the common feature depends on the modest regenerative capacity of the human heart after any important injury damaging the myocardium. Therefore, the more frequent consequence is the appearance of scar tissue, with collagen deposition and tissue remodelling. Even is some proliferation of cardiac myocites has been noted, this process is unable to overcome the destruction of normal cells observed in the several cardiac disorders, so that the only efficient response is usually the cellular hypertrophy.