Ischemia Modified Albumin as an Acute-Phase Reactant

REVIEW, February 2011, VOL I ISSUE III, ISSN 2042-4884
10.5083/ejcm.20424884.33 , Cite or Link Using DOI
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Eftihia Sbarouni MD, FACC, FESC, Panagiota Georgiadou MD & Vassilis Voudris MD, FACC, FESC

Ischemia is a common underdiagnosed vascular emergency, which is associated with an adverse prognosis. It is initiated whenever the arterial flow cannot supply sufficient oxygen resulting to irreversible damage and cell death. The clinical assessment is essential for the timely diagnosis and intervention of this disorder. Yet, no laboratory test for ischemia is available for the diagnosis of this clinically challenging situation.


Ischemia-modified albumin (IMA) is regarded as a new sensitive marker of myocardial ischemia, in contrast to cardiac enzymes which are released when cardiac necrosis occurs. During an acute ischemic event, structural changes occur in the amino terminus of albumin, rapidly reducing its capacity to bind transition metal ions and generate a metabolic variant of the albumin referred as IMA.